1. Introduction to Pharmacology
2. ADME & PHARMACOCINETICS
3. Principles of drug action (drug-receptor interactions)
4. Molecular aspects of drug action (pharmacological targets, receptor types, ion channels, enzymes and transport proteins)
5. Pharmacological regulation of cellular functions
6. Molecular aspects of the pharmacological action on synaptic function
Topics will include the basic principles of pharmacology and
major classes of therapeutic agents, with attention to their mechanisms
Student has to know the drugs discovery procedure and the implications of drug therapy of systemic
Basic and Clinical Pharmacology (LANGE Basic Science) by Bertram Katzung, Susan Masters , Anthony Trevor.
Written test, multiple choice
Sources of drugs. Targets of drug action and safety. Preclinical research. Clinical trials. Pharmacovigilance. Prescription Writing.
Passage of drugs across membrane barriers. Drug absorption, bioavailability, and routes of administration. Bioequivalence. Distribution of drugs.
Scope and aims of pharmacokinetics; Utility of pharmacokinetics in pharmacotherapy and drug development; Pharmacokinetic parameters (Ke, Clearance, Vd, t1/2); Steady-state; Relationship between persistence in the body and effect; Passage through biological membranes; Cell barriers; Absorption, Biological dosage (bioassay), Bioavailability, Pre-systemic elimination; Binding to plasma proteins and Pharmaco-toxicological consequences of plasma protein binding displacement, Drug interactions; Accumulation and storage tissues; Renal and biliary excretion; Dose-concentration relationship, saturation kinetics; Kinetic variability: influence of genetic factors, interactions, pathologies; Metabolism of drugs; Enzymatic induction: mechanisms and kinetics, pharmacological and toxicological consequences; Enzymatic inhibition: mechanisms and kinetics, pharmacological and toxicological consequences, main inhibitors of CYP450; Genetic polymorphism of metabolizing enzymes. Important Drug Interactions & Their Mechanisms.
Pharmacodynamics: relationship dose/effects; series of doses; ED50, LD50, Therapeutic window; Receptors: Classification, Structural, Functional Organization And Pharmacological Modulation; Ionotropic Receptors And Metabotropic Receptors; Methods For The Study Of Membrane Receptors;Protein Kinases And Their Role In Signal Transduction; Regulation Of Intracellular Calcium Homeostasis; Voltage-Deprendent Ion Channels; Neurotransporters: Molecular Structure, Activation Mechanisms And Pharmacological Modulation Of Neurotransporters; Neurotransmitters: Cholinergic Transmission, Catecholaminergic Transmission, Serotonergic Transmission, Gabaergic Transmission, Excitatory Amino Acid Transmission, Nitric Oxide, Opioid System, Cannabinoids.
Gender Pharmacology. "Biotech" drugs: monoclonal antibodies, antisense oligonucleotides. Nanotechnologies in pharmacology.